diff --git a/homeassistant/components/qnap_qsw/sensor.py b/homeassistant/components/qnap_qsw/sensor.py
index 45ec1828b9d73efb6a0af77c7c5782e4eccd9f81..e7f2c18638f1b7f78343e1dddfc55b7227519b1b 100644
--- a/homeassistant/components/qnap_qsw/sensor.py
+++ b/homeassistant/components/qnap_qsw/sensor.py
@@ -27,12 +27,9 @@ from aioqsw.const import (
     QSD_TEMP_MAX,
     QSD_TX_OCTETS,
     QSD_TX_SPEED,
-    QSD_UPTIME_SECONDS,
     QSD_UPTIME_TIMESTAMP,
 )
 
-from homeassistant.components.automation import automations_with_entity
-from homeassistant.components.script import scripts_with_entity
 from homeassistant.components.sensor import (
     SensorDeviceClass,
     SensorEntity,
@@ -45,10 +42,8 @@ from homeassistant.const import (
     UnitOfDataRate,
     UnitOfInformation,
     UnitOfTemperature,
-    UnitOfTime,
 )
 from homeassistant.core import HomeAssistant, callback
-from homeassistant.helpers import entity_registry as er, issue_registry as ir
 from homeassistant.helpers.entity_platform import AddEntitiesCallback
 from homeassistant.helpers.typing import UNDEFINED, StateType
 from homeassistant.util import dt as dt_util
@@ -68,16 +63,6 @@ class QswSensorEntityDescription(SensorEntityDescription, QswEntityDescription):
     value_fn: Callable[[str], datetime | StateType] = lambda value: value
 
 
-DEPRECATED_UPTIME_SECONDS = QswSensorEntityDescription(
-    translation_key="uptime",
-    key=QSD_SYSTEM_TIME,
-    entity_category=EntityCategory.DIAGNOSTIC,
-    native_unit_of_measurement=UnitOfTime.SECONDS,
-    state_class=SensorStateClass.TOTAL_INCREASING,
-    subkey=QSD_UPTIME_SECONDS,
-)
-
-
 SENSOR_TYPES: Final[tuple[QswSensorEntityDescription, ...]] = (
     QswSensorEntityDescription(
         translation_key="fan_1_speed",
@@ -355,46 +340,6 @@ async def async_setup_entry(
             )
             entities.append(QswSensor(coordinator, _desc, entry, port_id))
 
-    # Can be removed in HA 2025.5.0
-    entity_reg = er.async_get(hass)
-    reg_entities = er.async_entries_for_config_entry(entity_reg, entry.entry_id)
-    for entity in reg_entities:
-        if entity.domain == "sensor" and entity.unique_id.endswith(
-            ("_uptime", "_uptime_seconds")
-        ):
-            entity_id = entity.entity_id
-
-            if entity.disabled:
-                entity_reg.async_remove(entity_id)
-                continue
-
-            if (
-                DEPRECATED_UPTIME_SECONDS.key in coordinator.data
-                and DEPRECATED_UPTIME_SECONDS.subkey
-                in coordinator.data[DEPRECATED_UPTIME_SECONDS.key]
-            ):
-                entities.append(
-                    QswSensor(coordinator, DEPRECATED_UPTIME_SECONDS, entry)
-                )
-
-                entity_automations = automations_with_entity(hass, entity_id)
-                entity_scripts = scripts_with_entity(hass, entity_id)
-
-                for item in entity_automations + entity_scripts:
-                    ir.async_create_issue(
-                        hass,
-                        DOMAIN,
-                        f"uptime_seconds_deprecated_{entity_id}_{item}",
-                        breaks_in_ha_version="2025.5.0",
-                        is_fixable=False,
-                        severity=ir.IssueSeverity.WARNING,
-                        translation_key="uptime_seconds_deprecated",
-                        translation_placeholders={
-                            "entity": entity_id,
-                            "info": item,
-                        },
-                    )
-
     async_add_entities(entities)
 
 
diff --git a/homeassistant/components/qnap_qsw/strings.json b/homeassistant/components/qnap_qsw/strings.json
index 462e66a25c31b21573a261a56dd94193667f3518..e946bc4257d16a3a3c086e1eea0a9757771cfb27 100644
--- a/homeassistant/components/qnap_qsw/strings.json
+++ b/homeassistant/components/qnap_qsw/strings.json
@@ -57,11 +57,5 @@
         "name": "Uptime timestamp"
       }
     }
-  },
-  "issues": {
-    "uptime_seconds_deprecated": {
-      "title": "QNAP QSW uptime seconds sensor deprecated",
-      "description": "The QNAP QSW uptime seconds sensor entity is deprecated and will be removed in HA 2025.2.0.\nHome Assistant detected that entity `{entity}` is being used in `{info}`\n\nYou should remove the uptime seconds entity from `{info}` then click submit to fix this issue."
-    }
   }
 }
diff --git a/tests/components/qnap_qsw/test_sensor.py b/tests/components/qnap_qsw/test_sensor.py
index 16335e878fddf4cbcb79d1c0e559870d98e2ef16..1f56efded1691d69ed8daff9cf4af1777af7c7fb 100644
--- a/tests/components/qnap_qsw/test_sensor.py
+++ b/tests/components/qnap_qsw/test_sensor.py
@@ -1,14 +1,12 @@
 """The sensor tests for the QNAP QSW platform."""
 
-from unittest.mock import patch
-
 from freezegun.api import FrozenDateTimeFactory
 import pytest
 
 from homeassistant.components.qnap_qsw.const import ATTR_MAX, DOMAIN
 from homeassistant.const import Platform
 from homeassistant.core import HomeAssistant
-from homeassistant.helpers import entity_registry as er, issue_registry as ir
+from homeassistant.helpers import entity_registry as er
 
 from .util import async_init_integration, init_config_entry
 
@@ -383,39 +381,6 @@ async def test_qnap_qsw_create_sensors(
     assert state.state == "0"
 
 
-@pytest.mark.usefixtures("entity_registry_enabled_by_default")
-async def test_deprecated_uptime_seconds(
-    hass: HomeAssistant,
-    entity_registry: er.EntityRegistry,
-    issue_registry: ir.IssueRegistry,
-) -> None:
-    """Test deprecation warning of the Uptime seconds sensor entity."""
-    original_id = "sensor.qsw_m408_4c_uptime"
-    domain = Platform.SENSOR
-
-    config_entry = init_config_entry(hass)
-
-    entity = entity_registry.async_get_or_create(
-        domain=domain,
-        platform=DOMAIN,
-        unique_id=original_id,
-        config_entry=config_entry,
-        suggested_object_id=original_id,
-        disabled_by=None,
-    )
-
-    assert entity_registry.async_get_entity_id(domain, DOMAIN, original_id)
-
-    with patch(
-        "homeassistant.components.qnap_qsw.sensor.automations_with_entity",
-        return_value=["item"],
-    ):
-        await async_init_integration(hass, config_entry=config_entry)
-        assert issue_registry.async_get_issue(
-            DOMAIN, f"uptime_seconds_deprecated_{entity.entity_id}_item"
-        )
-
-
 async def test_cleanup_deprecated_uptime_seconds(
     hass: HomeAssistant,
     entity_registry: er.EntityRegistry,